Everything about Malate Dehydrogenase totally explained
Malate dehydrogenase is an
enzyme in the
citric acid cycle that
catalyzes the conversion of
malate into
oxaloacetate (using
NAD+) and vice versa (this is a
reversible reaction). Malate dehydrogenase isn't to be confused with malic enzyme, which catalyzes the conversion of
pyruvate using
NADPH.
Malate dehydrogenase is also involved in
gluconeogenesis, the synthesis of glucose from smaller molecules. Pyruvate in the mitochondria is acted upon by pyruvate carboxylase to form oxaloacetate, a citric acid cycle intermediate. In order to get the oxaloacetate out of the mitochondria, malate dehydrogenase reduces it to malate, and it then traverses the inner mitochondrial membrane. Once in the cytosol, the malate is oxidized back to oxaloacetate by cytosolic malate dehydrogenase. Finally,
phosphoenol-pyruvate carboxy kinase (PEPCK) converts oxaloacetate to phosphoenol pyruvate.
The
Cas number for this type of the enzyme is [9001-64-3].
Further Information
Get more info on 'Malate Dehydrogenase'.
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